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Development of nanoparticle-delivery systems for antiviral agents: A review.

Authors
  • Delshadi, Rana1
  • Bahrami, Akbar2
  • McClements, David Julian3
  • Moore, Matthew D4
  • Williams, Leonard5
  • 1 Food Science and Technology Graduate, Menomonie, WI, USA.
  • 2 Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC 28081, USA.
  • 3 Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: [email protected]
  • 4 Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: [email protected]
  • 5 Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC 28081, USA. Electronic address: [email protected]
Type
Published Article
Journal
Journal of controlled release : official journal of the Controlled Release Society
Publication Date
Jan 13, 2021
Volume
331
Pages
30–44
Identifiers
DOI: 10.1016/j.jconrel.2021.01.017
PMID: 33450319
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The COVID-19 pandemic has resulted in unprecedented increases in sickness, death, economic disruption, and social disturbances globally. However, the virus (SARS-CoV-2) that caused this pandemic is only one of many viruses threatening public health. Consequently, it is important to have effective means of preventing viral transmission and reducing its devastating effects on human and animal health. Although many antivirals are already available, their efficacy is often limited because of factors such as poor solubility, low permeability, poor bioavailability, un-targeted release, adverse side effects, and antiviral resistance. Many of these problems can be overcome using advanced antiviral delivery systems constructed using nanotechnology principles. These delivery systems consist of antivirals loaded into nanoparticles, which may be fabricated from either synthetic or natural materials. Nevertheless, there is increasing emphasis on the development of antiviral delivery systems from natural substances, such as lipids, phospholipids, surfactants, proteins, and polysaccharides, due to health and environmental issues. The composition, morphology, dimensions, and interfacial characteristics of nanoparticles can be manipulated to improve the handling, stability, and potency of antivirals. This article outlines the major classes of antivirals, summarizes the challenges currently limiting their efficacy, and highlights how nanoparticles can be used to overcome these challenges. Recent studies on the application of antiviral nanoparticle-based delivery systems are reviewed and future directions are described. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

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