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[Development of intravital bone tissue imaging and future perspectives of new lines of therapies for bone diseases.]

Authors
  • Ishii, Masaru1
  • 1 Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan. , (Japan)
Type
Published Article
Journal
Clinical calcium
Publication Date
Jan 01, 2018
Volume
28
Issue
2
Pages
167–174
Identifiers
DOI: CliCa1802167174
PMID: 29371480
Source
Medline
License
Unknown

Abstract

Recent advances in live imaging technology for 'seeing the unseen' phenomenon has been so enormous to revolutionize the diverse fields of biomedical sciences. We have so far pioneered to exploit the technique into the analyses of live bone tissues and made it possible to detect dynamic movements of single cells and multicellular interaction in intact bone tissues. Now that the cutting-edge techniques have been matured enough, we can also utilize this for validation of pharmacological actions in various regimens in vivo as well as for novel drug discovery for treating against bone diseases. In this brief review, I describe the overview of the studies related to intravital bone imaging and its application and contribution for future medicine in this field.

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