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Development of glutamatergic innervation during maturation of adult-born neurons

Authors
  • Dieni, Cristina V.
  • Wieckert, Adam J.
  • Overstreet-Wadiche, Linda
Type
Published Article
Journal
Frontiers in Biology
Publisher
Higher Education Press
Publication Date
Jul 10, 2015
Volume
10
Issue
4
Pages
310–320
Identifiers
DOI: 10.1007/s11515-015-1362-2
Source
Springer Nature
Keywords
License
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Abstract

The dentate gyrus is the entrance of the hippocampal formation and a primary target of excitatory afferents from the entorhinal cortex that carry spatial and sensory information. Mounting evidence suggests that continual adult neurogenesis contributes to appropriate processing of cortical information. The ongoing integration of adult born neurons dynamically modulates connectivity of the network, potentially contributing to dentate cognitive function. Here we review the current understanding of how glutamatergic innervation develops during the progression of adult-born neuron maturation. Summarizing the developmental stages of dentate neurogenesis, we also demonstrate that new neurons at an immature stage of maturation begin to process afferent activity from both medial and lateral entorhinal cortices.

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