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Development of a fumonisin-sensitive Saccharomyces cerevisiae indicator strain and utilization for activity testing of candidate detoxification genes

Authors
  • Krska, Tamara
  • Twaruschek, Krisztian
  • Valente, Nina
  • Mitterbauer, Rudolf
  • Moll, Dieter
  • Wiesenberger, Gerlinde
  • Berthiller, Franz
  • Adam, Gerhard
Type
Published Article
Journal
Applied and Environmental Microbiology
Publisher
American Society for Microbiology
Publication Date
Dec 06, 2023
Volume
89
Issue
12
Identifiers
DOI: 10.1128/aem.01211-23
Source
ASM Journals
Keywords
License
Green

Abstract

Fumonisins can cause diseases in animals and humans consuming Fusarium-contaminated food or feed. The search for microbes capable of fumonisin degradation, or for enzymes that can detoxify fumonisins, currently relies primarily on chemical detection methods. Our constructed fumonisin B1-sensitive yeast strain can be used to phenotypically detect detoxification activity and should be useful in screening for novel fumonisin resistance genes and to elucidate fumonisin metabolism and resistance mechanisms in fungi and plants, and thereby, in the long term, help to mitigate the threat of fumonisins in feed and food.

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