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Development of a fluid-structure interaction model to simulate mitral valve malcoaptation.

Authors
  • Hassani, Kamran1
  • Karimi, Alireza2
  • Dehghani, Ali1
  • Tavakoli Golpaygani, Ali3
  • Abdi, Hamed1
  • Espino, Daniel M4
  • 1 1 Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran. , (Iran)
  • 2 2 Department of Mechanical Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, Japan. , (Japan)
  • 3 3 Department of Biomedical Engineering, Standard Research Institute, Karaj, Iran. , (Iran)
  • 4 4 Department of Mechanical Engineering, University of Birmingham, Birmingham, UK.
Type
Published Article
Journal
Perfusion
Publisher
SAGE Publications
Publication Date
Nov 03, 2018
Identifiers
DOI: 10.1177/0267659118811045
PMID: 30394849
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Mitral regurgitation (MR) is a condition in which the mitral valve does not prevent the reversal of blood flow from the left ventricle into the left atrium. This study aimed at numerically developing a model to mimic MR and poor leaflet coaptation and also comparing the performance of a normal mitral valve to that of the MR conditions at different gap junctions of 1, 3 and 5 mm between the anterior and posterior leaflets. The results revealed no blood flow to the left ventricle when a gap between the leaflets was 0 mm. However, MR increased this blood flow, with increases in the velocity and pressure within the atrium. However, the pressure within the aorta did not vary meaningfully (ranging from 22 kPa for a 'healthy' model to 25 kPa for severe MR). The findings from this study have implications not only for understanding the changes in pressure and velocity as a result of MR in the ventricle, atrium or aorta, but also for the development of a computational model suitable for clinical translation when diagnosing and determining treatment for MR.

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