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Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study.

Authors
  • Hunter, Kylie E1
  • Webster, Angela C1
  • Clarke, Mike2
  • Page, Matthew J3
  • Libesman, Sol1
  • Godolphin, Peter J4
  • Aberoumand, Mason1
  • Rydzewska, Larysa H M4
  • Wang, Rui5
  • Tan, Aidan C1
  • Li, Wentao5
  • Mol, Ben W5
  • Willson, Melina1
  • Brown, Vicki6
  • Palacios, Talia1
  • Seidler, Anna Lene1
  • Aidan Tan
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Jan 01, 2022
Volume
17
Issue
10
Identifiers
DOI: 10.1371/journal.pone.0275893
PMID: 36219622
Source
Medline
Language
English
License
Unknown

Abstract

Individual participant data meta-analyses enable detailed checking of data quality and more complex analyses than standard study-level synthesis of summary data based on publications. However, there is limited existing guidance on the specific systematic checks that should be undertaken to confirm and enhance data quality for individual participant data meta-analyses and how to conduct these checks. We aim to address this gap by developing a checklist of items for data quality checking and cleaning to be applied to individual participant data meta-analyses of randomised trials. This study will comprise three phases: 1) a scoping review to identify potential checklist items; 2) two e-Delphi survey rounds among an invited panel of experts followed by a consensus meeting; and 3) pilot testing and refinement of the checklist, including development of an accompanying R-markdown program to facilitate its uptake.

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