The aim of this study was to evaluate the feasibility of a cancer-themed escape room as a learning activity for pharmacy students. A cancer-themed escape room was developed with four activities linked to patient assessment, communication, therapeutics and calculations. Twenty-six groups of six students challenged the escape room. Outcomes included student performance measures and resources required. A SWOC (strengths, weaknesses, opportunities, and challenges) analysis was also conducted. A total of 20 student groups (77%) successfully escaped. The average escape time was 22 min. The SWOC analysis identified strengths of student engagement, opportunities for expansion, weaknesses related to student preparation, and some logistical challenges. A cancer-themed escape room is a viable learning tool for pharmacy students. © 2020 Royal Pharmaceutical Society.