Affordable Access

deepdyve-link
Publisher Website

Development of a beam propagation method to simulate the point spread function degradation in scattering media

Authors
  • Cheng, Xiaojun1, 2
  • Li, Yunzhe3
  • Mertz, Jerome1, 2
  • SakadŽić, Sava4
  • Devor, Anna2, 4, 5
  • Boas, David A.1, 2
  • Tian, Lei3, 2
  • 1 Department of Biomedical Engineering, Boston University, Massachusetts 02215, USA
  • 2 Neurophotonics Center, Boston University Massachusetts 02215, USA
  • 3 Department of Electrical and Computer Engineering, Boston University, Massachusetts 02215, USA
  • 4 Optics Division at the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
  • 5 Departments of Neurosciences and Radiology, University of California, San Diego, California 92093, USA
Type
Published Article
Journal
Optics Letters
Publisher
The Optical Society
Publication Date
Oct 15, 2019
Volume
44
Issue
20
Pages
4989–4992
Identifiers
DOI: 10.1364/OL.44.004989
PMID: 31613246
PMCID: PMC6889808
Source
PubMed Central
License
Unknown

Abstract

Scattering is one of the main issues that limit the imaging depth in deep tissue optical imaging. To characterize the role of scattering, we have developed a forward model based on the beam propagation method and established the link between the macroscopic optical properties of the media and the statistical parameters of the phase masks applied to the wavefront. Using this model, we have analyzed the degradation of the point-spread function of the illumination beam in the transition regime from ballistic to diffusive light transport. Our method provides a wave-optic simulation toolkit to analyze the effects of scattering on image quality degradation in scanning microscopy. Our open-source implementation is available at https://github.com/BUNPC/Beam-Propagation-Method .

Report this publication

Statistics

Seen <100 times