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Development of Autologous Platelet-Rich Plasma Mixed-Microfat as an Advanced Therapy Medicinal Product for Intra-Articular Injection of Radio-Carpal Osteoarthritis: From Validation Data to Preliminary Clinical Results

Authors
  • Mayoly, Alice
  • Iniesta, Aurélie
  • Curvale, Caroline
  • Kachouh, Najib
  • Jaloux, Charlotte
  • Eraud, Julia
  • Vogtensperger, Marie
  • Veran, Julie
  • Grimaud, Fanny
  • Jouve, Elisabeth
  • Casanova, Dominique
  • Sabatier, Florence
  • Legré, Régis
  • Magalon, Jérémy
Publication Date
Mar 05, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

40 mm according to the visual analog scale (VAS) were treated. Microfat-PRP ATMP is a product with high platelet purity, conserved viability of stromal vascular fraction cells, chondrogenic differentiation capacity in vitro and high secretion of IL-1Ra anti-inflammatory cytokine. For patients, the only side effect was pain at the adipose tissue harvesting sites. Potential efficacy was observed with a pain decrease of over 50% (per VAS score) and the achievement of minimal clinically important differences for DASH and PRWE functional scores at one year in all three patients. Microfat-PRP ATMP presented a good safety profile after an injection in wrist OA. Efficacy trials are necessary to assess whether this innovative strategy could delay the necessity to perform non-conservative surgery.

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