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Development of auditory brainstem circuitry

Authors
  • Friauf, E.
  • Lohmann, Christian
Type
Published Article
Journal
Cell and Tissue Research
Publisher
Springer-Verlag
Publication Date
Jul 01, 1999
Volume
297
Issue
2
Pages
187–195
Identifiers
DOI: 10.1007/s004410051346
Source
Springer Nature
Keywords
License
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Abstract

Despite its complexity, the neural circuitry in the auditory brainstem of vertebrates displays a fascinating amount of order. How is this order established in such a precise manner during ontogeny? In this review, we will summarize evidence for both activity-independent and activity-dependent processes involved in the generation of the auditory brainstem circuitry of birds and mammals. An example of activity-independent processes is the emergence of crude topography, which, most probably, is determined by molecular markers whose expression is genetically controlled. On the other hand, neuronal activity supports cell survival, affects dendritic and axonal growth, and influences fine tuning of maps. It appears that various types of neuronal activity, namely spontaneous versus acoustically evoked, bilateral versus unilateral, uncoordinated versus patterned, play a role during different aspects of development and cooperate with the activity-independent processes to ensure the proper formation of neuronal circuitry.

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