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Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets.

Authors
  • Ferraris, Davide M1
  • Miggiano, Riccardo2
  • Rossi, Franca3
  • Rizzi, Menico4
  • 1 Department of Pharmaceutical Sciences, Università del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy. [email protected] , (Italy)
  • 2 Department of Pharmaceutical Sciences, Università del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy. [email protected] , (Italy)
  • 3 Department of Pharmaceutical Sciences, Università del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy. [email protected] , (Italy)
  • 4 Department of Pharmaceutical Sciences, Università del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy. [email protected] , (Italy)
Type
Published Article
Journal
Pathogens (Basel, Switzerland)
Publication Date
Feb 01, 2018
Volume
7
Issue
1
Identifiers
DOI: 10.3390/pathogens7010017
PMID: 29389854
Source
Medline
Keywords
License
Unknown

Abstract

Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure of tuberculosis involves prolonged therapies which complicate the compliance and monitoring of drug administration and treatment. Moreover, the only available antitubercular vaccine fails to provide an effective shield against adult lung tuberculosis, which is the most prevalent form. Hence, there is a pressing need for effective antitubercular drugs and vaccines. This review highlights recent advances in the study of selected M. tuberculosis key molecular determinants of infection and vulnerable targets whose structures could be exploited for the development of new antitubercular agents.

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