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Determining fetal manganese exposure from mantle dentine of deciduous teeth.

Authors
  • Arora, Manish1
  • Bradman, Asa
  • Austin, Christine
  • Vedar, Michelle
  • Holland, Nina
  • Eskenazi, Brenda
  • Smith, Donald R
  • 1 Environmental and Occupational Medicine and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [email protected]
Type
Published Article
Journal
Environmental Science & Technology
Publisher
American Chemical Society
Publication Date
May 01, 2012
Volume
46
Issue
9
Pages
5118–5125
Identifiers
DOI: 10.1021/es203569f
PMID: 22455722
Source
Medline
Language
English
License
Unknown

Abstract

Studies addressing health effects of manganese (Mn) excess or deficiency during prenatal development are hampered by a lack of biomarkers that can reconstruct fetal exposure. We propose a method using the neonatal line, a histological feature in deciduous teeth, to identify regions of mantle dentine formed at different prenatal periods. Micromeasurements of Mn in these regions may be used to reconstruct exposure at specific times in fetal development. To test our hypothesis, we recruited pregnant women before 20 weeks gestation from a cohort of farmworkers exposed to Mn-containing pesticides. We collected house floor dust samples and mother's blood during the second trimester; umbilical cord blood at birth; and shed deciduous incisors when the child was ∼7 years of age. Mn levels in mantle dentine formed during the second trimester (as (55)Mn:(43)Ca area under curve) were significantly associated with floor dust Mn loading (r(spearman) = 0.40; p = 0.0005; n = 72). Furthermore, (55)Mn:(43)Ca in sampling points immediately adjacent the neonatal line were significantly associated to Mn concentrations in cord blood (r(spearman) = 0.70; p = 0.003; n = 16). Our results support that Mn levels in mantle dentine are useful in discerning perinatal Mn exposure, offering a potentially important biomarker for the study of health effects due to environmental Mn exposure. © 2012 American Chemical Society

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