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Determinations of the inclusion complex between gossypol and beta-cyclodextrin.

Authors
  • Shen, Ying-lin
  • Ying, Wei
  • Yang, Sheng-hua
  • Wu, Long-min
Type
Published Article
Journal
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
Publisher
Elsevier
Publication Date
Sep 01, 2006
Volume
65
Issue
1
Pages
169–172
Identifiers
PMID: 16877036
Source
Medline
License
Unknown

Abstract

Features of the inclusion complex between gossypol (Gos) and beta-cyclodextrin (CD), such as its aqueous solubility, association constant, characteristics in the solid state and crystalline morphology, as well as the stoichiometry of this complex have been determined. The phase-solubility diagram drawn using UV detections belongs to an AN-type. Fluorescence detection and calculation with the modified Benesi-Hidebrond equation provide an 1:2 stoichiometry for the complex. Its apparent stability constant has been determined to be 3,203 M(-1) by fluorescence technique and confirmed by the calculation from UV spectroscopy. X-ray powder diffractions (XRD) and Scanning Electron Microscopy (SEM) observations showed a clear difference in the crystal morphology of the complex from those of both Gos and beta-CD.

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