Determination of varicella-zoster virus (VZV) immune status with the VIDAS VZV immunoglobulin G automated immunoassay and the VZVScan latex agglutination assay.
Infectious Disease Reference Laboratory, Providence Portland Medical Center, Oregon 97213, USA.
- Published Article
Clinical and Diagnostic Laboratory Immunology
American Society for Microbiology
- Publication Date
May 01, 1996
The VIDAS varicella-zoster virus (VZV) immunoglobulin G immunoassay and the VZVScan latex agglutination (LA) test were compared for the detection of VZV antibody in patient sera. Of 625 samples tested, 554 were positive for VZV antibody by one or both methods. Five hundred thirteen (82.1%) samples were positive by both methods, 71 (11.4%) were negative by both methods, and there were 41 (6.6%) discrepant samples. Statistically significant differences in sensitivity and specificity were not found (P = 0.37); however, several observations were made. All 23 VIDAS repeat equivocal samples were LA positive. Fifty-four samples showed prozone effects with the LA assay, all of which resolved as positive.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/8705687