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Determination of transverse relaxation rate for estimating iron deposits in central nervous system.

Authors
  • Hikita, Tachio
  • Abe, Kazuo
  • Sakoda, Saburo
  • Tanaka, Hisashi
  • Murase, Kenya
  • Fujita, Norihiko
Type
Published Article
Journal
Neuroscience research
Publication Date
Jan 01, 2005
Volume
51
Issue
1
Pages
67–71
Identifiers
PMID: 15596242
Source
Medline
License
Unknown

Abstract

To determine the amount of iron deposits in the basal ganglia, we examined 13 healthy volunteers with a 1.5 T MRI system using three transverse relaxation rates measured with two sequences. The transverse relaxation rates comprise the reversible contribution (R2') and irreversible contribution (R2) to a phase-reversal 180 degrees -pulse sequence. The transverse relaxation rates with the estimated iron indicated that both R2 and R2' had a robust relationship with brain iron level as determined from published post mortem data. This was the case only when the analyses are limited to the subcortical gray matter regions, however. R2' was affected by macroscopic magnetic field inhomogeneity arising from the skull bases, so that it was less robust for estimating the amount of iron deposits in the basal ganglia.

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