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Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia

Authors
  • Coppens, Marc
  • Anssens, S
  • Parashchanka, Aliaksandra
  • Roelens, Kristien
  • Deschepper, Ellen
  • De Hert, Stefan
  • Wouters, Patrick
Publication Date
Jan 01, 2017
Source
Ghent University Institutional Archive
Keywords
Language
English
License
Unknown
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Abstract

The primary goal of this study was to determine the median effective dose (ED50) of spinal chloroprocaine for labour analgesia. Thirty-eight parturients requesting neuraxial analgesia were enrolled. Doses of 1% chloroprocaine were determined by the technique of up-down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal-epidural, which was then supplemented with an epidural dose of 7.5 mu g sufentanil in 7 ml saline. Effective analgesia was defined as a score <= 10 mm within 15 min on a 100-mm visual analogue pain scale. Using the isotonic regression estimator method, the ED50 of chloroprocaine for the spinal component of a combined spinal-epidural for labour was calculated to be median (95%CI) 12.0 (9.3-17.0) mg.

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