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Determination of impurities in nucleoside 3′-phosphoramidites by fast atom bombardment mass spectrometry

Authors
  • Toren, Paul C.
  • Betsch, David F.
  • Weith, H.Lee
  • Coull, James M.
Type
Published Article
Journal
Analytical Biochemistry
Publisher
Elsevier BV
Publication Date
Jan 01, 1986
Volume
152
Issue
2
Pages
291–294
Identifiers
DOI: 10.1016/0003-2697(86)90411-2
Source
Elsevier
Keywords
License
Unknown

Abstract

Negative-ion fast atom bombardment mass spectrometry is quite useful for the identification of products and by-products formed during the synthesis of nucleoside 3′-phosphoramidites. The data shown that detritylation and oxidation are side reactions which occur during the synthesis of monomeric units used in the construction of oligodeoxyribonucleotides by the phosphite triester method.

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