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The determination of flux through phenylalanine hydroxylase and homogentisate oxidase in isolated hepatocytes.

Authors
  • Fisher, M J
  • Pogson, C I
Type
Published Article
Journal
Bioscience reports
Publication Date
Oct 01, 1984
Volume
4
Issue
10
Pages
835–841
Identifiers
PMID: 6518276
Source
Medline
License
Unknown

Abstract

The metabolic fate of [4-3H]phenylalanine incubated with isolated hepatocytes has been investigated. Analysis of 3H2O production and fluorimetric estimation of tyrosine production has allowed calculation of flux through phenylalanine hydroxylase and homogentisate oxidase. The resulting flux determinations are physiologically relevant and hormonally sensitive.

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