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Determination of CYP2C19 phenotype in black Americans with omeprazole: correlation with genotype.

Authors
  • Marinac, J S
  • Balian, J D
  • Foxworth, J W
  • Willsie, S K
  • Daus, J C
  • Owen, R
  • Flockhart, D A
Type
Published Article
Journal
Clinical pharmacology and therapeutics
Publication Date
Aug 01, 1996
Volume
60
Issue
2
Pages
138–144
Identifiers
PMID: 8823231
Source
Medline
License
Unknown

Abstract

The 2% prevalence rate of poor CYP2C19 metabolizers in this healthy black population residing in the Midwestern United States is similar to that reported in white subjects and in the Shona population of Zimbabwe but much less than in Asian subjects. Omeprazole is a safe and specific probe of the CYP2C19 enzyme system that correlates well with genotype.

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