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[The determination of clozapine in blood and urine by gas chromatography-mass spectrometry].

Authors
  • Melent'ev, A B
  • Kurochkina, I V
Type
Published Article
Journal
Sudebno-meditsinskaia ekspertiza
Publication Date
Jan 01, 1999
Volume
42
Issue
4
Pages
27–29
Identifiers
PMID: 10467865
Source
Medline
License
Unknown

Abstract

A method for measuring closapine in the blood and urine by gas chromatography-mass spectrometry as a trifluoroacetic derivative is proposed. The threshold level for closapine detection is 25 ng/ml in the blood and 30 ng/ml in the urine. Calibration curves are linear in the range 0.025-5 mcg/ml for the blood and 0.03-50 mcg/ml for the urine. The method can be used in forensic chemical and clinical toxicological analysis.

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