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Determination of boron by inductively coupled plasma atomic emission spectroscopy. Biodistribution of 10B in tumor-bearing mice

Authors
  • Tsygankova, A. R.1, 2
  • Kanygin, V. V.1
  • Kasatova, A. I.1, 3
  • Zav’yalov, E. L.1, 4
  • Gusel’nikova, T. Ya.2
  • Kichigin, A. I.1, 4
  • Mukhamadiyarov, R. A.5
  • 1 Novosibirsk National Research State University, 2 ul. Pirogova, Novosibirsk, 630090, Russian Federation , Novosibirsk (Russia)
  • 2 Siberian Branch of the Russian Academy of Sciences, 3 prosp. Akad. Lavrent’eva, Novosibirsk, 630090, Russian Federation , Novosibirsk (Russia)
  • 3 Siberian Branch of the Russian Academy of Sciences, 11 prosp. Akad. Lavrent’eva, Novosibirsk, 630090, Russian Federation , Novosibirsk (Russia)
  • 4 Siberian Branch of the Russian Academy of Sciences, 10/2 prosp. Akad. Lavrent’eva, Novosibirsk, 630090, Russian Federation , Novosibirsk (Russia)
  • 5 Research Institute for Complex Issues of Cardiovascular Diseases, 6 Sosnovii bulvar, Kemerovo, 650002, Russian Federation , Kemerovo (Russia)
Type
Published Article
Journal
Russian Chemical Bulletin
Publisher
Springer US
Publication Date
Mar 01, 2020
Volume
69
Issue
3
Pages
601–607
Identifiers
DOI: 10.1007/s11172-020-2805-8
Source
Springer Nature
Keywords
License
Yellow

Abstract

The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of 10B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated.

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