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Detection of regulatory cells as an assay for allograft tolerance in miniature swine.

Authors
  • Wu, Anette
  • Yamada, Kazuhiko
  • Baron, Christophe
  • Mathes, David W
  • Monajati, Leila M
  • Vagefi, Parsia A
  • Sachs, David H
Type
Published Article
Journal
The Journal of Heart and Lung Transplantation
Publisher
Elsevier
Publication Date
Feb 01, 2004
Volume
23
Issue
2
Pages
210–217
Identifiers
PMID: 14761769
Source
Medline
License
Unknown

Abstract

This coculture assay appears to correlate with the presence of tolerance under conditions applicable to the clinical setting. The assay appears to identify peripheral regulatory mechanisms of tolerance in allogeneic transplant recipients, and therefore may provide an approach for determining an appropriate timepoint at which to test withdrawal of immunosuppressive medications.

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