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Detection and monitoring of trisomy 8 by fluorescence in situ hybridization in acute myeloid leukemia: a multicentric study.

Authors
  • Cuneo, A1
  • Bigoni, R
  • Roberti, M G
  • Bardi, A
  • Rigolin, G M
  • Piva, N
  • Mancini, M
  • Nanni, M
  • Alimena, G
  • Mecucci, C
  • Matteucci, C
  • La Starza, R
  • Bernasconi, P
  • Cavigliano, P
  • Genini, E
  • Zaccaria, A
  • Testoni, N
  • Carboni, C
  • Castoldi, G
  • 1 Institute of Hematology, University of Ferrara, Italy.
Type
Published Article
Journal
Haematologica
Publication Date
January 1998
Volume
83
Issue
1
Pages
21–26
Identifiers
PMID: 9542319
Source
Medline
License
Unknown

Abstract

It is concluded that FISH was a valuable method in this multicentric study since it showed greater sensitivity than CCA in detecting minor clones with +8, in patients with both normal and abnormal karyotypes. The role of FISH in the cytogenetic follow-up of trisomies in AML patients may be promising.

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