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Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices.

Authors
  • Ko, Jina1
  • Carpenter, Erica2
  • Issadore, David3
  • 1 Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [email protected]
  • 2 Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • 3 Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [email protected] and Department of Electrical and Systems engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Type
Published Article
Journal
The Analyst
Publisher
The Royal Society of Chemistry
Publication Date
Jan 21, 2016
Volume
141
Issue
2
Pages
450–460
Identifiers
DOI: 10.1039/c5an01610j
PMID: 26378496
Source
Medline
License
Unknown

Abstract

In the last several years, nanoscale vesicles that originate from tumor cells and which can be found circulating in the blood (i.e. exosomes and microvesicles) have been discovered to contain a wealth of proteomic and genetic information to monitor cancer progression, metastasis, and drug efficacy. However, the use of exosomes and microvesicles as biomarkers to improve patient care has been limited by their small size (30 nm-1 μm) and the extensive sample preparation required for their isolation and measurement. In this Critical Review, we explore the emerging use of micro and nano-technology to isolate and detect exosomes and microvesicles in clinical samples and the application of this technology to the monitoring and diagnosis of cancer.

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