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Detection of a gamma interferon-induced protein IP-10 in psoriatic plaques.

Authors
  • Gottlieb, A B
  • Luster, A D
  • Posnett, D N
  • Carter, D M
Type
Published Article
Journal
The Journal of experimental medicine
Publication Date
Sep 01, 1988
Volume
168
Issue
3
Pages
941–948
Identifiers
PMID: 2459293
Source
Medline
License
Unknown

Abstract

The pathologic features of psoriatic plaques are inflammation and increased epidermal turnover. IP-10, a cytokine the expression of which is induced by gamma-interferon, is a member of a family of soluble mediators with inflammatory and growth-promoting activities. IP-10 protein was detected in keratinocytes and the dermal infiltrate from active psoriatic plaques using an affinity-purified rabbit anti-IP-10 antibody in immunoperoxidase studies. Successful treatment of active plaques decreased IP-10 expression in plaques. These results were corroborated by Northern blot analysis with an IP-10 cDNA probe. We have previously detected activated T cells and HLA-DR keratinocytes in active psoriatic plaques. Since IP-10 is detected in delayed cellular immune responses, the present study further points to the role of ongoing cellular immune responses in the pathogenesis of psoriasis.

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