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Detection of epithelial-cell injury, and quantification of infection, in the HCT-8 organoid model of cryptosporidiosis.

Authors
  • Alcantara Warren, Cirle1
  • Destura, Raul V
  • Sevilleja, Jesus Emmanuel A D
  • Barroso, Luis F
  • Carvalho, Humberto
  • Barrett, Leah J
  • O'Brien, Alison D
  • Guerrant, Richard L
  • 1 Center for Global Health, University of Virginia, Charlottesville,VA 22901, USA. [email protected]
Type
Published Article
Journal
The Journal of infectious diseases
Publication Date
Jul 01, 2008
Volume
198
Issue
1
Pages
143–149
Identifiers
DOI: 10.1086/588819
PMID: 18498239
Source
Medline
License
Unknown

Abstract

The HCT-8 organoid displayed morphologic changes indicative of successful and quantifiable infection with C. parvum. The HCT-8 organoid-culture system may have application in interventional in vitro studies of cryptosporidiosis.

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