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[Detection of different class (subclass) antibodies in sera of patients with schistosomiasis japonica for diagnosis and efficiency evaluation].

Authors
  • Li, Y
  • Zeng, X
  • Yi, X
  • Tian, M
Type
Published Article
Journal
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
Publication Date
Jan 01, 1997
Volume
22
Issue
5
Pages
381–383
Identifiers
PMID: 10073013
Source
Medline
License
Unknown

Abstract

The subclass antibodies against IgG1, IgG3 and IgG4 in sera of the patients with chronic Schistosomiasis japonica were detected before treatment, and after treatment--6 and 12 months respectively, using Biotin-Avidin-ELISA (BA-ELISA) established by purified 31/32 KD antigen from the adult worms. At the same time IgG1 and IgM were examined by the standard ELISA. False positive reaction with normal control and cross reaction with other parasitic diseases have not been observed. The IgG1 and IgG3 subclasses showed high sensitivity and specificity and reduced quickly 6 months after treatment. These results indicate that the level of specific IgG1 and IgG4 to the 31/32 KD adult worm protein has high value for diagnosis of Schistosomiasis japonica and evaluation of the curative efficiency of the disease.

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