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Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated Quality Control

Authors
  • Sitron, Cole S.
  • Brandman, Onn
Type
Published Article
Journal
Annual Review of Biochemistry
Publisher
Annual Reviews
Publication Date
Jun 20, 2020
Volume
89
Pages
417–442
Identifiers
DOI: 10.1146/annurev-biochem-013118-110729
Source
Annual Reviews
Keywords
License
Yellow

Abstract

Stalled protein synthesis produces defective nascent chains that can harm cells. In response, cells degrade these nascent chains via a process called ribosome-associated quality control (RQC). Here, we review the irregularities in the translation process that cause ribosomes to stall as well as how cells use RQC to detect stalled ribosomes, ubiquitylate their tethered nascent chains, and deliver the ubiquitylated nascent chains to the proteasome. We additionally summarize how cells respond to RQC failure.

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