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Detection of Clostridium difficile toxin by enzyme immunoassay, tissue culture test and culture.

Authors
  • Liesenfeld, O
  • Saeger, F
  • Hahn, H
Type
Published Article
Journal
Infection
Publication Date
Jan 01, 1994
Volume
22
Issue
1
Pages
29–32
Identifiers
PMID: 8181838
Source
Medline
License
Unknown

Abstract

Clostridium difficile toxin is frequently encountered in patients with antibiotic-associated diarrhea. A commercially available enzyme immunoassay (EIA) detecting toxins A and B was evaluated, screening 148 stool specimens specifically submitted for the detection of C. difficile. A sensitivity of 100% and a specificity of 97.5% were found compared to a tissue culture assay. The overall prevalence of C. difficile toxin was 22.1%. Cephalosporins had been administered significantly more often to toxin-positive patients. The EIA proved to be a suitable test for the detection of C. difficile toxin, revealing high prevalences in specifically submitted clinical specimens.

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