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Design of a tribocorrosion bioreactor for the analysis of immune cell response to in situ generated wear products.

Authors
  • Pourzal, Robin
  • Cichon, R
  • Mathew, M T
  • Pacione, C A
  • Fischer, A
  • Hallab, Nadim James
  • Wimmer, Markus
Type
Published Article
Journal
Journal of long-term effects of medical implants
Publication Date
Jan 01, 2014
Volume
24
Issue
1
Pages
65–76
Identifiers
PMID: 24941407
Source
Medline
License
Unknown

Abstract

Adverse local tissue reactions to wear debris and corrosion products have lead to a sharp decline in the use of metal-on-metal (MOM) total hip athroplasties (THAs) clinically. Today, approximately 1 million patients are still carrying such a device. To gain a better understanding of the effect of wear and corrosion products on cells within the joint environment, it is important to generate conditions in vitro that resemble the in vivo system as closely as possible. In this paper, we present a novel tribocorrosion bioreactor that enables the simultaneous conduction of tribocorrosion and cell-culture experiments. In this setup, macrophage cell cultures are located in direct proximity to a tribological interface mimicking the sliding conditions of THA and are exposed to wear and corrosion products as they are generated. These products may include meta-stable species and metallo-organic complexes that have not been considered in earlier studies. The combination of standard tribological, electrochemical, and biological techniques is associated with several challenges that are described here in detail.

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