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Design and synthesis of a new furan-steroid-propanone derivative using some chemical strategies.

Authors
  • Lauro, Figueroa-Valverde1
  • Marcela, Rosas-Nexticapa2
  • Maria, Lopez-Ramos3
  • Francisco, Diaz Cedillo4
  • Alejandra, Garcimarero-Espino E5
  • Virginia, Mateu-Armand6
  • Yazmin, Ortiz-Ake3
  • 1 Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kalá s/n, 24085 San Francisco de Campeche, Mexico. Electronic address: [email protected] , (Mexico)
  • 2 Facultad de Nutrición, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010 Xalapa, Veracruz, Mexico. Electronic address: [email protected] , (Mexico)
  • 3 Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kalá s/n, 24085 San Francisco de Campeche, Mexico. , (Mexico)
  • 4 Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala s/n Col, Santo Tomas, D.F. C.P. 11340, Mexico. , (Mexico)
  • 5 Facultad de Medicina, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010 Xalapa, Veracruz, Mexico. , (Mexico)
  • 6 Facultad de Nutrición, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010 Xalapa, Veracruz, Mexico. , (Mexico)
Type
Published Article
Journal
Steroids
Publication Date
Aug 01, 2020
Volume
160
Pages
108654–108654
Identifiers
DOI: 10.1016/j.steroids.2020.108654
PMID: 32439408
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

There are several reports for the preparation of furan derivatives using some protocols which requires special conditions. In this way, the aim of this study was to synthesize a new furan-steroid-propanone derivative from both 17α-ethynylestradiol and 2-nitro-17α-ethynylestradiol using some series of reactions such as aldolization, 2 + 2 addition and etherification. The chemical structure was evaluated through both 1H NMR and 13C NMR spectroscopic analysis. The results showed a good yielding from furan-steroid derivative. In conclusion, this investigation provides a facile synthesis of a new furan-steroid-propanone derivative, using some reagents which are not expensive and do not require special conditions for handling. Copyright © 2020 Elsevier Inc. All rights reserved.

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