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Design, synthesis and evaluation of anti-inflammatory, analgesic and antibacterial activity of 2, 4, 6-trisubstituted quinazoline derivatives

Authors
  • Jain, Nivrati
  • Jain, Harshita
  • Jain, Ashish
  • Ravichandran, Veerasamy
  • Jain, Prateek
Type
Published Article
Journal
Ovidius University Annals of Chemistry
Publisher
Sciendo
Publication Date
Oct 01, 2018
Volume
29
Issue
2
Pages
97–97
Identifiers
DOI: 10.2478/auoc-2018-0014
Source
De Gruyter
Keywords
License
Green

Abstract

We described here the synthesis and biological evaluation of a series of 2, 4, 6-trisubstituted quinazoline derivatives as potential anti-inflammatory, analgesic and antibacterial agents. The synthesized compounds were characterized by FTIR, 1H NMR and mass spectroscopy analysis. We found that the compounds 6b, 6e, 6g, 6h and 6j showed better anti-inflammatory activity than indomethacin. Compounds 6b, 6e, 6h, 6j and 6l were found to exhibit appreciable analgesic activity, and 6b, 6g and 6k showed good antibacterial activity against Gram (+) bacteria: B. subtilis, S. aureus, S. epidermis, and Gram (-) bacteria: E. coli, P. aeruginosa and K. pneumoniae. Compound 6b showed overall better anti-inflammatory, analgesic and antibacterial activity among the synthesized compounds. The results of the present study could be helpful for the designing of effective anti-inflammatory, analgesic and antibacterial agents.

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