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Design, synthesis, and antiviral activity evaluation of phenanthrene-based antofine derivatives.

Authors
  • Wang, Ziwen
  • Wei, Peng
  • Xizhi, Xu
  • Liu, Yuxiu
  • Wang, Lizhong
  • Wang, Qingmin
Type
Published Article
Journal
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society
Publication Date
Sep 05, 2012
Volume
60
Issue
35
Pages
8544–8551
Identifiers
DOI: 10.1021/jf302746m
PMID: 22880628
Source
Medline
License
Unknown

Abstract

On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthrene-based antofine derivatives (1-12 and 18-50) were designed targeting tobacco mosaic virus (TMV) RNA and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 19 and 27 displayed higher activity than commercial Ribavirin, thus emerging as potential inhibitors of plant virus. The novel concise structure provides another new template for antiviral studies.

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