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[Design push-pull osmotic pump tablets of famotidine based on an expert system for the formulation design of osmotic pump of poor water-soluble drug].

Authors
  • Zhang, Zhi-Hong
  • Jin, Jie
  • Zhang, Hong-Wu
  • Xin, Wei
  • Jia, Guo-Bin
  • Wu, Wen-Fang
  • Pan, Wei-San
Type
Published Article
Journal
Yao xue xue bao = Acta pharmaceutica Sinica
Publication Date
Jan 01, 2011
Volume
46
Issue
1
Pages
109–114
Identifiers
PMID: 21465816
Source
Medline
License
Unknown

Abstract

The purpose of this study is to design push-pull osmotic pump (PPOP) tablets of famotidine using the expert system for the formulation design of osmotic pump of poor water-soluble drug which had been established by the authors. Firstly, the parameters which were requisite of the system input were obtained from literatures and experimental tests. Then the parameters were input into the system, and the program was run. The system displayed the designed formulations sequential. Finally, famotidine PPOP was prepared according to the designed formulations and the in vitro dissolution was carried out. It was found out that the target formulation of famotidine PPOP which could release for 24 hours was obtained in a very short period. Meanwhile, the practicability of the established expert system was proved.

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