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Design of new anticancer therapies targeting cell cycle checkpoint pathways.

Authors
  • Sampath, D
  • Plunkett, W
Type
Published Article
Journal
Current Opinion in Oncology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Nov 01, 2001
Volume
13
Issue
6
Pages
484–490
Identifiers
PMID: 11673689
Source
Medline
License
Unknown

Abstract

The mammalian cell cycle is exquisitely controlled by the cyclin-dependent kinases, which regulate cell cycle progression. Cell cycle transitions are, in turn, controlled by checkpoints that monitor the integrity and replication status of the genetic material before cells commit to either replicate or segregate their DNA. On activation, checkpoints interface with cyclin-Cdk complexes to block the cell cycle. Pharmacologic compounds that exploit our current knowledge of cell cycle and checkpoint pathway regulation offer insights into the development of novel therapeutic strategies.

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