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Design of a biofluid-absorbing bioactive sandwich-structured Zn-Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing.

Authors
  • Zhang, Zhaowenbin1, 2
  • Li, Wenbo3
  • Liu, Ying4
  • Yang, Zhigang4
  • Ma, Lingling1, 2
  • Zhuang, Hui1, 2
  • Wang, Endian1, 2
  • Wu, Chengtie1, 2
  • Huan, Zhiguang1, 2
  • Guo, Feng3
  • Chang, Jiang1, 2
  • 1 State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, People's Republic of China. , (China)
  • 2 Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China. , (China)
  • 3 Department of Plastic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, PR China. , (China)
  • 4 Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China. , (China)
Type
Published Article
Journal
Bioactive Materials
Publisher
KeAi Publishing
Publication Date
Jul 01, 2021
Volume
6
Issue
7
Pages
1910–1920
Identifiers
DOI: 10.1016/j.bioactmat.2020.12.006
PMID: 33364530
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The deep burn skin injures usually severely damage the dermis with the loss of hair follicle loss, which are difficult to regenerate. Furthermore, severe burns often accompanied with large amount of wound exudates making the wound moist, easily infected, and difficult to heal. Therefore, it is of great clinical significance to develop wound dressings to remove wound exudates and promote hair follicle regeneration. In this study, a sandwich-structured wound dressing (SWD) with Janus membrane property was fabricated by hot compression molding using hydrophilic zinc silicate bioceramics (Hardystonite, ZnCS) and hydrophobic polylactic acid (PLA). This unique organic/inorganic Janus membrane structure revealed excellent exudate absorption property and effectively created a dry wound environment. Meanwhile, the incorporation of ZnCS bioceramic particles endowed the dressing with the bioactivity to promote hair follicle regeneration and wound healing through the release of Zn2+ and SiO3 2- ions, and this bioactivity of the wound dressing is mainly attributed to the synergistic effect of Zn2+ and SiO3 2- to promote the recruitment, viability, and differentiation of hair follicle cells. Our study demonstrates that the utilization of the Janus membrane and synergistic effect of different type bioactive ions are effective approaches for the design of wound dressings for burn wound healing. © 2020 [The Author/The Authors].

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