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A description of two cases of factor V deficiency.

Authors
  • Cerneca, F1
  • Parco, E1
  • Simeone, R1
  • Bembi, B1
  • Giorgi, R1
  • 1 Servizio Analisi Chimico-Cliniche, Laboratorio di Patologia dell'Emostasi Istituto per l'Infanzia 'Burlo Garofulo', via dell'Istria 65/1, 34137 Trieste, Italy.*Servizio Analisi Chimico-Cliniche, Laboratorio di Patologia dell'Emostasi, Istituto per l'infanzia 'Burlo Garofolo'. Trieste, Italy.Servizio Analisi Chimico-Cliniche, Laboratorio di Patologia dell'Emostasi, Istituto per l'Infanzia 'Burlo Garofolo', Trieste, Italy.Pediatric Clinic, IRCSS Burlo Garofolo, Trieste, Italy.Pediatric Clinic, IRCSS Burlo Garofolo, Trieste, Italy. , (Italy)
Type
Published Article
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
Publication Date
Jul 01, 1995
Volume
1
Issue
3
Pages
200–201
Identifiers
DOI: 10.1111/j.1365-2516.1995.tb00069.x
PMID: 27214541
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We report two cases of factor V deficiency. A 12-year-old girl with thalassemia major was admitted for bone marrow transplant (mismatched). She was found to have a heterozygous deficiency of factor V (21%), but this was considered compatible with the transplant, which was performed without the support of suppernatant cryoprecipitate. A 14-year-old girl (factor V 2%) with a negative history (menarche at age 12, menstrual cycle regular and normal in quantity and length). One year previously she had complained of menorrhagia (length of period, 9 days); tests revealed server anaemia (Hb 4.9 g/dl). We show how even severe cases of factor V deficiency may often be silent, and not require transfusion in surgical procedures, thus avoiding the risks associated with such therapy.

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