The two-ligand model for allosteric regulation of complex polymeric enzymes is offered. Two types of cooperative interactions are observed--the cooperative transformations inside the promoter and interactions of promoters themselves--along with the direct interaction of two ligands inside each subunit. The solution of the model is given and its kinetic properties are discussed.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/3370238