Affordable Access

Access to the full text

Desaturation during exercise is not a sufficient mechanism for prediction of osteoporosis in non-cystic fibrosis bronchiectasis

Authors
  • Tomlinson, Owen W.1
  • Vlachopoulos, Dimitris1
  • 1 University of Exeter, St Luke’s Campus, Heavitree Road, Exeter, Devon, EX1 2LU, UK , Exeter (United Kingdom)
Type
Published Article
Journal
BMC pulmonary medicine
Publication Date
Jan 28, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12890-020-1055-8
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundRecent research has proposed an association between desaturation during a six minute walking test (6MWT) and osteoporosis in an elderly group of individuals with non-cystic fibrosis bronchiectasis. A causative pathway through activation of hypoxia-inducible factor 1-alpha (HIF-1α) has been proposed.CommentaryQueries regarding the statistical approaches used are identified and discussed within this correspondence. These predominate around the use of linear regression models to predict osteoporosis in a group that is already osteoporotic, presenting with extreme values for bone mineral density (BMD). Further queries are raised regarding the HIF-1α pathway, and physical activity (PA) is proposed as an upstream mechanism for both reduced exercise tolerance and low BMD.ConclusionsIt is suggested that osteoporosis cannot be predicted in a group that is already osteoporotic, and that PA is likely to be the causative mechanism between desaturation in the 6MWT and low BMD in non-cystic fibrosis bronchiectasis.

Report this publication

Statistics

Seen <100 times