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Dermatologic and dental aspects of the 2012 International Tuberous Sclerosis Complex Consensus Statements.

Authors
  • Teng, Joyce M C
  • Cowen, Edward W
  • Wataya-Kaneda, Mari
  • Gosnell, Elizabeth S
  • Witman, Patricia M
  • Hebert, Adelaide A
  • Mlynarczyk, Greg
  • Soltani, Keyoumars
  • Darling, Thomas N
Type
Published Article
Journal
JAMA dermatology
Publication Date
Oct 01, 2014
Volume
150
Issue
10
Pages
1095–1101
Identifiers
DOI: 10.1001/jamadermatol.2014.938
PMID: 25029267
Source
Medline
License
Unknown

Abstract

Skin and dental findings comprise 4 of 11 major features and 3 of 6 minor features in the diagnostic criteria. A definite diagnosis of TSC is defined as the presence of at least 2 major features or 1 major and 2 or more minor features; in addition, a pathological mutation in TSC1 or TSC2 is diagnostic. Skin and oral examinations should be performed annually and every 3 to 6 months, respectively. Intervention may be indicated for TSC skin or oral lesions that are bleeding, symptomatic, disfiguring, or negatively affecting function. Options presented include surgical excision, laser(s), or use of a mammalian target of rapamycin inhibitor.

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