Affordable Access

deepdyve-link
Publisher Website

Deriving functional human enteroendocrine cells from pluripotent stem cells

Authors
  • Sinagoga, Katie L.1
  • McCauley, Heather A.1
  • Múnera, Jorge O.1
  • Reynolds, Nichole A.2
  • Enriquez, Jacob R.1
  • Watson, Carey3
  • Yang, Hsiu-Chiung2
  • Helmrath, Michael A.3, 4
  • Wells, James M.1, 4, 5
  • 1 Cincinnati Children's Hospital Medical Center, Division of Developmental Biology, 3333 Burnet Ave, Cincinnati, OH 45229-3039
  • 2 Eli Lilly and Company, Indianapolis, IN 46285, USA, Endocrine/Cardiovascular Division
  • 3 Cincinnati Children's Hospital Medical Center, Division of Pediatric General and Thoracic Surgery, 3333 Burnet Ave, Cincinnati, OH 45229-3039
  • 4 Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039
  • 5 Cincinnati Children's Hospital Medical Center, Division of Endocrinology, 3333 Burnet Ave, Cincinnati, OH 45229-3039
Type
Published Article
Journal
Development
Publisher
The Company of Biologists
Publication Date
Oct 01, 2018
Volume
145
Issue
19
Identifiers
DOI: 10.1242/dev.165795
PMID: 30143540
PMCID: PMC6198470
Source
PubMed Central
Keywords
License
Unknown

Abstract

Summary: Manipulation of developmental signaling pathways and transcription factor expression allows differentiation of human pluripotent stem cells into nutrient-responsive, intestinal enteroendocrine cells.

Report this publication

Statistics

Seen <100 times