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Deregulated expression of promyelocytic leukemia zinc finger protein in B-cell chronic lymphocytic leukemias does not affect cyclin A expression.

Authors
  • Parrado, A
  • Noguera, M E
  • Delmer, A
  • McKenna, S
  • Davies, J
  • Le Gall, I
  • Bentley, P
  • Whittaker, J A
  • Sigaux, F
  • Chomienne, C
  • Padua, R A
Type
Published Article
Journal
The hematology journal : the official journal of the European Haematology Association / EHA
Publication Date
Jan 01, 2000
Volume
1
Issue
1
Pages
15–27
Identifiers
PMID: 11920165
Source
Medline
License
Unknown

Abstract

The lower survival of patients with the highest levels of PLZF suggests that this protein may be a marker of progression in B-CLL. The absence of co-ordinated regulation of PLZF and cyclin A genes in B-CLL and in a malignant B-cell line may indicate a loss of cyclin A control by PLZF in B-CLL and other B-cell disorders. Deregulation of PLZF could thus play a role in B-cell malignancy.

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