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der(1)t(1;9): a specific chromosome abnormality in polycythemia vera? Cytogenetic and in situ hybridization studies.

Authors
  • den Nijs van Weert, J I
  • Beverstock, G C
  • Kievits, T
  • Haak, H L
  • Havik-Bogaard, F C
  • Leeksma, C H
Type
Published Article
Journal
Cancer Genetics and Cytogenetics
Publisher
Elsevier
Publication Date
Jul 01, 1989
Volume
40
Issue
1
Pages
121–127
Identifiers
PMID: 2758394
Source
Medline
License
Unknown

Abstract

Two patients with polycythemia vera and an extra der(1)t(1;9) chromosome are reported. In one patient this was found as the sole abnormality. The other patient originally presented with trisomy 9 but later developed an extra der(1) during the further course of the disease with disapperance of the extra chromosome 9. In situ hybridization studies on this latter patient proved that the centromere of chromosome 1 was involved in the formation of the derivative chromosome.

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