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Depression of respiration induced by metabolic acidosis in newborn lambs.

Authors
  • Bureau, M A
  • Bégin, R
Type
Published Article
Journal
Biology of the neonate
Publication Date
Jan 01, 1982
Volume
42
Issue
5-6
Pages
279–283
Identifiers
PMID: 7159632
Source
Medline
License
Unknown

Abstract

The present study evaluates the strength of the drive to breathe and the respiratory response of newborns to metabolic acidosis. The study consisted in a HCl mild and severe acidosis induced in 30 unanesthetized newborn lambs aged from 2 to 90 days. During mild acidosis (pHa = 7.20), all lambs experienced an increase in the minute ventilation (VE) associated with an increase in the neuromuscular drive of breathing which was measured by the occlusion pressure (PO.1). However, with severe acidosis (pHA = 7.10) both VE and PO.1 decreased towards the preacidotic level in the 2- and 10-day-old lambs but continued to increase in older lambs. It is concluded that newborn lambs have an immature drive of breathing and a blunted respiratory output to metabolic acidosis.

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