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[The dependence of serum opsonic activity on fibronectin and alpha- 1 acid glycoprotein levels in children with burns].

Authors
  • Melezyńska-Matej, M
  • Koziełł, J
  • Tołkacz, M
  • Czernik, J
  • Grzybek-Hryncewicz, K
Type
Published Article
Journal
Pediatria polska
Publication Date
Jun 01, 1996
Volume
71
Issue
6
Pages
511–516
Identifiers
PMID: 8756769
Source
Medline
License
Unknown

Abstract

The concentration of acute phase proteins following burn is known to increase in serum rapidly, while that of fibronectin often decreases. Fibronectin (Fn) has been demonstrated to serve as an opsonin involved in the ingestion phase in phagocytic process. On the other hand, some acute phase proteins such as alpha-1 acid glycoprotein (AG) may inhibit phagocytic activity. In our study, the phagocytic activity of normal granulocytes was decreased by those sera in which a high level of AG was accompanied by a fall in the Fn Level. Attempts to detect a possible link between the acute phase response and fibronectin led as to study whether fibronectin and AG may interact antagonistically on the phagocytic activity of neutrophils. For this reason we calculated the Fn/Ag coefficient. We showed that an Fn/Ag coefficient in normal sera equals more than 0.20. The higher the coefficient, the better the opsonic activity of sera. We propose here that an Fn/AG coefficient may be a useful risk factor for infections in burned patients.

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