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Denudatin A, a Dimeric Acylphloroglucinol from Hypericum denudatum Presents an Antinociceptive Effect in Mice.

Authors
  • Bridi, Henrique1
  • Meirelles, Gabriela de Carvalho1
  • Bordignon, Sérgio Augusto de Loreto2
  • Rates, Stela Maris Kuze1
  • von Poser, Gilsane Lino1
  • 1 Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. , (Brazil)
  • 2 Programa de Pós Graduação em Avaliação de Impactos Ambientais, UNILASALLE, Canoas, Brazil. , (Brazil)
Type
Published Article
Journal
Planta Medica
Publisher
Georg Thieme Verlag KG
Publication Date
Nov 01, 2017
Volume
83
Issue
17
Pages
1329–1334
Identifiers
DOI: 10.1055/s-0043-109567
PMID: 28472841
Source
Medline
License
Unknown

Abstract

A new dimeric acylphloroglucinol, denudatin A (1), was isolated from the flowering aerials parts of Hypericum denudatum, along with the known phloroglucinols selancin A (2), hyperbrasilol A (3), uliginosin B (4), and isouliginosin B (5). The structure of 1 was elucidated using 1D, 2D NMR, and MS experiments, and by comparison with previously reported data for Hypericum dimeric acylphloroglucinols. Denudatin A (1) and selancin A (2) were administered orally to mice displaying antinociceptive activity in the hot plate test. The compounds did not induce motor impairment in the rotarod apparatus.

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