Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity

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Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity

Publisher
BioMed Central
Publication Date
Jan 01, 2006
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

bcr1408.fm Available online http://breast-cancer-research.com/content/8/2/R24 Open AccessVol 8 No 2Research article Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity Debra Hawes1, Susan Downey2, Celeste Leigh Pearce3, Sue Bartow4, Peggy Wan3, Malcolm C Pike3 and Anna H Wu3 1Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA 2Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA 3Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA 4107 Stark Mesa, Carbondale, CO 81623, USA Corresponding author: Malcolm C Pike, [email protected] Received: 2 Feb 2006 Revisions requested: 21 Feb 2006 Revisions received: 8 Mar 2006 Accepted: 30 Mar 2006 Published: 28 Apr 2006 Breast Cancer Research 2006, 8:R24 (doi:10.1186/bcr1408) This article is online at: http://breast-cancer-research.com/content/8/2/R24 © 2006 Hawes et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Increased mammographic density is a strong risk factor for breast cancer. The reasons for this are not clear; two obvious possibilities are increased epithelial cell proliferation in mammographically dense areas and increased breast epithelium in women with mammographically dense breasts. We addressed this question by studying the number of epithelial cells in terminal duct lobular units (TDLUs) and in ducts, and their proliferation rates, as they related to local breast densities defined hist

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