Densanins A and B, new macrocyclic pyrrole alkaloids isolated from the marine sponge Haliclona densaspicula.
Department of Oceanography, Kunsan National University, Jeonbuk 573-701, South Korea.
- Published Article
American Chemical Society
- Publication Date
Dec 21, 2012
Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On the basis of spectral data and the Mosher ester method, the complete structures were characterized as hexacyclic diamine alkaloids, which were probably derived from 3-alkylpyridine. Compounds 1 and 2 showed relatively potent inhibitory effects on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells with IC(50) values of 1.05 and 2.14 μM, respectively.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/23211017