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Densanins A and B, new macrocyclic pyrrole alkaloids isolated from the marine sponge Haliclona densaspicula.

Authors
  • Hwang, Buyng Su1
  • Oh, Jung Soon
  • Jeong, Eun Ju
  • Sim, Chung J
  • Rho, Jung-Rae
  • 1 Department of Oceanography, Kunsan National University, Jeonbuk 573-701, South Korea. , (North Korea)
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Dec 21, 2012
Volume
14
Issue
24
Pages
6154–6157
Identifiers
DOI: 10.1021/ol3028303
PMID: 23211017
Source
Medline
License
Unknown

Abstract

Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On the basis of spectral data and the Mosher ester method, the complete structures were characterized as hexacyclic diamine alkaloids, which were probably derived from 3-alkylpyridine. Compounds 1 and 2 showed relatively potent inhibitory effects on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells with IC(50) values of 1.05 and 2.14 μM, respectively.

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