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Dendritic domains with hexagonal symmetry formed by x-shaped bolapolyphiles in lipid membranes.

Authors
  • Werner, Stefan
  • Ebert, Helgard
  • Lechner, Bob-Dan
  • Lange, Frank
  • Achilles, Anja
  • Bärenwald, Ruth
  • Poppe, Silvio
  • Blume, Alfred
  • Saalwächter, Kay
  • Tschierske, Carsten
  • Bacia, Kirsten
Type
Published Article
Journal
Chemistry - A European Journal
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jun 07, 2015
Volume
21
Issue
24
Pages
8840–8850
Identifiers
DOI: 10.1002/chem.201405994
PMID: 25940233
Source
Medline
Keywords
License
Unknown

Abstract

A novel class of bolapolyphile (BP) molecules are shown to integrate into phospholipid bilayers and self-assemble into unique sixfold symmetric domains of snowflake-like dendritic shapes. The BPs comprise three philicities: a lipophilic, rigid, π-π stacking core; two flexible lipophilic side chains; and two hydrophilic, hydrogen-bonding head groups. Confocal microscopy, differential scanning calorimetry, XRD, and solid-state NMR spectroscopy confirm BP-rich domains with transmembrane-oriented BPs and three to four lipid molecules per BP. Both species remain well organized even above the main 1,2-dipalmitoyl-sn-glycero-3-phosphocholine transition. The BP molecules only dissolve in the fluid membrane above 70 °C. Structural variations of the BP demonstrate that head-group hydrogen bonding is a prerequisite for domain formation. Independent of the head group, the BPs reduce membrane corrugation. In conclusion, the BPs form nanofilaments by π stacking of aromatic cores, which reduce membrane corrugation and possibly fuse into a hexagonal network in the dendritic domains.

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