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Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment.

Authors
  • Liau, Linda M
  • Prins, Robert M
  • Kiertscher, Sylvia M
  • Odesa, Sylvia K
  • Kremen, Thomas J
  • Giovannone, Adrian J
  • Lin, Jia-Wei
  • Chute, Dennis J
  • Mischel, Paul S
  • Cloughesy, Timothy F
  • Roth, Michael D
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Aug 01, 2005
Volume
11
Issue
15
Pages
5515–5525
Identifiers
PMID: 16061868
Source
Medline
License
Unknown

Abstract

Together, our results suggest that the absence of bulky, actively progressing tumor, coupled with low TGF-beta(2) expression, may identify a subgroup of glioma patients to target as potential responders in future clinical investigations of dendritic cell-based vaccines.

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